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Keywords

Cinnamon nanoparticles
chlorhexidine
gel
salivary biomarker
chronic gingivitis

Abstract

Aims:  The study aimed to evaluate the  anti-inflammatory effects  of  nanocinnamon gel  on salivary concentrations of cytokines: interleukine-6( IL-6) and tumor necrosis factor-alpha ( TNF-α) in chronic gingivitis.Material and Methods: prepared nanocinnamon gel 2% concentration  from nanocinnamon powder. The  study  was carried out on the randomized clinical trial of chronic gingivitis  comprises of 45 patients of  age between (18-50)years old .They  were  divided  into three  groups, fifteen  for  each  group , treatment involved  mechanical therapy  by scaling and polishing  at  dental  clinic and  drug treatment in which   the first  group applied to the  mechanical treatment  alone, , second  group  received  chlorhexidine  gel topically and  third  group received  nanocinnamon  gel topically , the treated groups  used the  gel  twice  daily at  least  ten  minute  for three  weeks. Unstimulated saliva was collected for each individuals and at least two hours  after any food intake to disregard the food stimulatory effect on salivary secretions. ELISA kits (Enzyme Linked Immunosorbent Assay) used to measure IL-6 and TNF-α in saliva . Data  were  analyzed  using  kruscal-wallias H test and  Friedmans̓ test  analysis  range test. Results: the  results of  present  study showed that there  were no significant differences in salivary  IL-6  among  groups  after treatment  however ,  there  were significantly decreasing  in  salivary TNF-α  of  nanocinnamon group  after  21 days  of  interval therapy  in comparison to  control  group. Conclusion :The use of nanocinnamon gel have anti-inflammatory effect against gingivitis and the changes in the salivary concentrations of IL-6  and TNF-α  can help in the diagnosis of periodontal disease
https://doi.org/10.33899/rden.2020.127851.1047
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