Abstract
In this study, aqueous extract of propolis, which is a natural bee product, tested for treatment of recurrent aphthus stomatitis (RAS). A total of 40 patients with RAS divided into 4 groups. Each patient received one of following pre-prepared mouthwash:Group A received aqueous propolis extract at 1% concentration.Group B received aqueous propolis extract at 0.5% concentration.Group C received dexamethosone at 0.1% concentration.Group D received distilled water. (Control group).The study was double blind and the patient instructed to use the mouthwashes for 5 min 3 times daily.The results of study showed signi-ficant difference between groups in pain score assessed at day 2 of study. High percentage of no pain recorded in group A comparing to other groups. However at 5 days of drug therapy no significant diff-erence noticed among the groups regard-ing pain score.For assessment of healing after 5 days, although no significant difference noticed among the groups, group A repor-ted to show high percentage of complete healing comparing to other groups. Also groups A, B and C showed 50% healing of ulcer comparing to only 20% in patient on group D.In conclusion, aqueous propolis ext-ract at 1% concentration showed good percentage of early reduction of pain score and rapid healing of ulcer with minimal side effect and further studies on other extract and concentration may be reco-mmended.
