Light Microscopic Investigation of Developing Rat Teeth After Atenolol Drug Administration (Experimental Study)
Al-Rafidain Dental Journal,
Volume 11, Issue 2, Pages 331-340
Aims: To investigate the effect of atenolol drug on the formation and development of rat dentition of rat (histologically and histochemically). Materials and Methods: Albino Wister rats were divided into two main groups,. The control group and experimental group, each consisted of (9) pregnant rats, giv-en 1 ml distilled water and 10 mg atenolol (powder) suspended in 1ml distilled water , orally , as a single dose, respectively from 12 – 18 day of gestation, after delivery of pregnanent rats, 36 newborn were selected to be scarified at ages 1, 5. and 10 post nataly from each group. The specimens were pre-pared for processing and stained with H&E and alcian blue stains. Results: The treated groups showed obvious histological changes: delay in tooth germ formation, increase blood vascularity, disorganiza-tion of ameloblast and odontoblast cells, and delay in glycosaminoglycan synthesis. Conclusions: Atenolol drug delay the rat tooth development causing abnormal odontogenic changes and inhibits gly-cosaminoglycan synthesis.
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