Aims: This study perfoemed were to evaluate the effectiveness of ethanolic extract of leaves (EEL) at different concentrations and latex (LX) of Ficus carica against Enterococcus faecalis, and to evaluate the most effective concentration of EEL and LX against Enterococcus faecalis in dentinal tubules when used as intracanal medicament. Materials and Methods:The different concentrations of EEL (5%,2.5%,1.25%,0.6%,0.3%,0.1%) and LX against Enterococcus faecalis was evaluated by broth mi-crodilution method using spectrophotometer. One hundred and twenty freshly extracted single canal humen teeth were chosen. They were section at cementoenamal junction, instrumented, sectioned apic-al one third, and then sterilized. They are then contaminated with Enterococcus faecalis solution and incubated. These samples divided into three groups randomly. Root canals filled with 5% EEL, LX, and formocrsol and maintained for one day for group one, for three days for group two, and seven days for group three. The medicaments removed from the canal and dentin chips was obtained from the can-al and weight 10 mg that will be diluted in brain heart infusion broth, and cultured on blood agar then the number of colonies recovery were estimated. Results: this study obtained that 5% EEL had best effect than other concentrations but its effect less than LX but significantly not different. Result also obtained that 5% EEL and LX capable after seven day to eliminate the Enterococcus faecalis from In-fected dentinal tubule, while formocresol can not. Conclusions: The EEL at 5% and LX had sufficient antibacterial effect against Enterococcus faecalis in the infected dentinal tubules when they are used as intracanal medicaments.