To evaluate the effects of systemically administered Alendronate sodium on osteoclastic activity and osteoblast accumulation. Materials and Methods: Fourty eight micro-screw implant, twelve adult rabbits were used in this study, the rabbits divided into two main groups, treated and control group, which further subdivided into three subgroups according to the healing periods after 2 weeks, 4 weeks and 6 weeks. All animal were treated with alendronate sodium. Eight micro-screw implants instilled in tibiaes of each tested subgroup and six instilled in tibiaes of control subgroups, the tissue facing the micro-screw implant subjected to histological evaluation for the tested subgroups and control sub-groups including the number of active osteoblast and osteoclast. Results: A significant differences be-tween subgroups 0WT, 2WT and 4WT, were more prominent for 2WT and 4WT subgroups from 0WT subgroups which showed score (+++), further no significant difference for control subgroups were all showed score (+++) for osteoblastic activity. For the active osteoclast a significant differences detected between subgroups of experimental and control sample, were score (+) noticed in the 0WT subgroups, score (+) in 2 readings and (++) in 6 readings of4WT subgroups and score (+++) for 4WT subgroups with no significant difference between experimental and control samples in 2 weeks, 4 weeks and 6 weeks healing periods .Conclusions: According to the result of histological evaluation, no estimated differences in the bone remodeling process had been detected between treated and the control group, which may need longer period of drug administration to probably induce effect on bone.