Aims: Tooth surface roughness is a fundamental feature that impact on the foreign materials retention and caries progression, as well is considered an effective tool for checking the efficacy of various remineralizing agents and evaluating the activity of the carious lesion, so the aim of this study is to test the effectiveness of various remineralizing agents (varnishes) and compare their efficiency on tooth surface roughness. The main ingredient of the used varnishes was (BioActive Glass: BAG), (Casein Phosphopeptide Amorphous Calcium Phosphate: CPP-ACP), (Silver Diamine Fluoride: SDF), and (5% Sodium Fluoride: NaF). Materials and Methods: Samples used in the experiment were (50) maxillary primary canine teeth, which were distributed randomly in 5 groups, each group has 10 teeth. Groups were: Group A: SDF, Group B: BAG, Group C: CPP-ACP, Group D: NaF, Group E: Control (just preserved in artificial saliva). The measurement of the surface roughness was achieved at 3 intervals: baseline reading, the 2nd reading was after immersing for 3 days in demineralizing solution and the final measurement was after 2 weeks of varnishes application. Results: The results revealed that Group C significantly decrease the surface roughness, followed by D, B Groups, with insignificant effect in Group A. Conclusions: Based on the findings of this study, varnish made up of CPP-ACP was the most efficacious one in reducing the surface roughness. The addition of Potassium Iodide to Silver Diamine Fluoride could diminish its capacity for surface roughness improvement.