Print ISSN: 1812-1217

Online ISSN: 1998-0345

Keywords : interleukin

Measurement of Interleukine-6 and C-reactive Protein in Serum of Patients on Amlodipine Therapy

Nahla Nahla O. Tawk; Rana Kh. Atarbashe

Al-Rafidain Dental Journal, 2015, Volume 15, Issue 2, Pages 444-447
DOI: 10.33899/rden.2015.160885

Aims: The aims of this study were to compare between the immunological parameters (serum interleukin-6 (IL-6) and c-reactive protein (CRP) of patients suffering from chronic cardiovascular diseases with amlodipine therapy and control group to determine the effects of the drug on those parameters. Materials and Methods: The study was conducted on 42 subjects, 27 patients already on amlodipine therapy, aged ranged between 34-75 years. Fifteen healthy subjects of the same age group participated in this study as a control group. The screening by medical history, examination (gingival enlargement scores) and blood samples to measure serum IL-6 and CRP was done once at base line visit. Results: The results obtained showed that amlodipine trherapy group had higher gingival overgrowth scores and immunological parameters than control group with significant difference at (p<0.05), also there was positive correlation but not significant between CRP in serum and IL-6 (p< 0.05). Conclusion: The study concluded that there is a significant difference in the GO score and immunological parameters in amlodipine therapy group as compared with healthy group.

Preoperative Alterations of Interleukin-6 levels During Surgical Removal of Impacted Lower Third Molar

Harith D Qadawi; Atalla F. Rejab; Mahmoud YM Taha

Al-Rafidain Dental Journal, 2014, Volume 14, Issue 1, Pages 76-81
DOI: 10.33899/rden.2014.89256

The aim of the study is to assess the blood levels of (interleukin-6) at different intervals of time after surgical removal of impacted lower third molars.. Materials and Methods: The study group comprised 26 patients with impacted lower third molars .All extractions were performed under local anaesthesia using the inferior alveolar nerve block together with vestibular infiltration. A buccal full thickness two sided mucoperiosteal flap was raised. Sterile low-speed straight hand pieces and sterile distilled water were used for ostectomy. After tooth removal the wound was closed with 3-0 black silk suture. Three blood samples were drawn from each patient; one before the operation, the second 2hr. post operation and the third 24hr. post operation. The blood samples were collected through venipunc-ture, serum separated and stored in at -20ºC. Analysis was performed using the Enzyme linked Im-munosourbant assay ( ELISA). Results: The level of IL-6, in this study, showed an increase following surgery, in comparison with the level before operation. This increase in the level of Interleukin-6 re-mained high until 24hr after operation. Conclusion: Interleukin-6 (IL-6) is higher after surgical extrac-tion of lower third molars and remained with high levels to 24hr. after operation